VCP anticorps (AA 704-806) (FITC)

N° du produit ABIN7179884

Cet anticorps Lapin Polyclonal détecte spécifiquement VCP dans . Il présente une réactivité envers Poisson zèbre (Danio rerio).

Aperçu rapide pour VCP anticorps (AA 704-806) (FITC) (ABIN7179884)

Antigène: VCP (Valosin Containing Protein (VCP))

Reactivité: Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VCP est conjugé à/à la FITC

Application: Veuillez nous consulter SVP

Détail du produit anti-VCP anticorps (FITC)

Épitope: AA 704-806

Réactivité croisée: Poisson zèbre (Danio rerio)

Purification: >95%, Protein G purified

Immunogène: Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur VCP

Antigène: VCP (Valosin Containing Protein (VCP))

Autre désignation: vcp

Sujet:

Background: Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity).

Aliases: vcp antibody, cdc48 antibody, si:ch211-113n10.2Transitional endoplasmic reticulum ATPase antibody, TER ATPase antibody, EC 3.6.4.6 antibody, Protein CDC48 antibody, Valosin-containing protein antibody, VCP antibody

UniProt: Q7ZU99

Pathways: ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Ubiquitin Proteasome Pathway