c-FOS anticorps (Thr232)

N° du produit ABIN7180011

L’anticorps Lapin Polyclonal anti-c-FOS a été validé pour WB et ELISA. Il convient pour détecter c-FOS dans des échantillons de Humain.

Aperçu rapide pour c-FOS anticorps (Thr232) (ABIN7180011)

Antigène: c-FOS (c-Fos) (c-Fos)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp c-FOS est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-c-FOS anticorps

Épitope: Thr232

Fonction: FOS (Ab-232) Antibody

Réactivité croisée: Souris

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized non-phosphopeptide derived from Human FOS around the phosphorylation site of threonine 232 (V-A-T(p)-P-E).

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur c-FOS

Antigène: c-FOS (c-Fos) (c-Fos)

Autre désignation: FOS

Sujet:

Background: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum.

van Straaten F., Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
Hai T., Genes Dev. 3:2083-2090(1989).
Heilig R., Nature 421:601-607(2003).

Aliases: Activator protein 1 antibody, AP 1 antibody, C FOS antibody, Cellular oncogene c fos antibody, Cellular oncogene fos antibody, FBJ murine osteosarcoma viral (v fos) oncogene homolog (oncogene FOS) antibody, FBJ murine osteosarcoma viral oncogene homolog antibody, FBJ murine osteosarcoma viral v fos oncogene homolog antibody, FBJ Osteosarcoma Virus antibody, FOS antibody, FOS protein antibody, FOS_HUMAN antibody, G0 G1 switch regulatory protein 7 antibody, G0/G1 switch regulatory protein 7 antibody, G0S7 antibody, Oncogene FOS antibody, p55 antibody, proto oncogene c Fos antibody, Proto oncogene protein c fos antibody, Proto-oncogene c-Fos antibody, v fos FBJ murine osteosarcoma viral oncogene homolog antibody

UniProt: P01100

Pathways: S100 Proteins