EPH Receptor B2 anticorps (C-Term)

N° du produit ABIN7180167

L’anticorps Lapin Polyclonal anti-EPH Receptor B2 a été validé pour WB et ELISA. Il convient pour détecter EPH Receptor B2 dans des échantillons de Humain.

Aperçu rapide pour EPH Receptor B2 anticorps (C-Term) (ABIN7180167)

Antigène: EPH Receptor B2 (EPHB2)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B2 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-EPH Receptor B2 anticorps

Épitope: C-Term

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from C-terminal of Human EPHB2.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur EPH Receptor B2

Antigène: EPH Receptor B2 (EPHB2)

Autre désignation: EPHB2

Sujet:

Background: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.

Kiyokawa E., Cancer Res. 54:3645-3650(1994).
Ikegaki N., Hum. Mol. Genet. 4:2033-2045(1995).
Tang X.X., Oncogene 17:521-526(1998).

Aliases: cek5 antibody, Developmentally regulated EPH related tyrosine kinase antibody, DRT antibody, EK5 antibody, ELK related protein tyrosine kinase antibody, Eph receptor B2 antibody, EPH tyrosine kinase 3 antibody, EPH-like kinase 5 antibody, EPHB2 antibody, EPHB2_HUMAN antibody, Ephrin type B receptor 2 antibody, Ephrin type-B receptor 2 antibody, EPHT 3 antibody, ERK antibody, ETECK antibody, hEK5 antibody, Nuk antibody, Prkm 5 antibody, Receptor protein tyrosine kinase HEK 5 antibody, Renal carcinoma antigen NY-REN-47 antibody, Sek 3 antibody, Tyro 5 antibody, Tyrosine protein kinase receptor CEK 5 antibody, Tyrosine protein kinase receptor EPH 3 antibody, Tyrosine protein kinase receptor QEK 5 antibody, Tyrosine-protein kinase receptor EPH-3 antibody, Tyrosine-protein kinase TYRO5 antibody

UniProt: P29323

Pathways: Signalisation RTK, Regulation of long-term Neuronal Synaptic Plasticity, S100 Proteins