STK36 anticorps

N° du produit ABIN7184207

Cet anticorps Lapin Polyclonal détecte spécifiquement STK36 dans WB, ELISA et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour STK36 anticorps (ABIN7184207)

Antigène: STK36 (serine/threonine Kinase 36 (STK36))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp STK36 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-STK36 anticorps

Fonction: STK36 Antibody

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from internal of Human STK36.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur STK36

Antigène: STK36 (serine/threonine Kinase 36 (STK36))

Autre désignation: STK36

Sujet:

Background: Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.

Murone M., Nat. Cell Biol. 2:310-312(2000).
Nagase T., DNA Res. 6:337-345(1999).
Hillier L.W., Nature 434:724-731(2005).

Aliases: FU antibody, Fused homolog antibody, KIAA1278 antibody, Serine/threonine kinase 36, fused homolog antibody, Serine/threonine protein kinase 36 fused homolog antibody, Serine/threonine-protein kinase 36 antibody, STK36 antibody, STK36_HUMAN antibody

UniProt: Q9NRP7