DNMT3B anticorps (N-Term)

N° du produit ABIN7184447

Cet anticorps Lapin Polyclonal détecte spécifiquement DNMT3B dans WB, IHC, ELISA et IF. Il présente une réactivité envers Humain.

Aperçu rapide pour DNMT3B anticorps (N-Term) (ABIN7184447)

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DNMT3B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Détail du produit anti-DNMT3B anticorps

Épitope: N-Term

Réactivité croisée: Humain

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from N-terminal of Human DNMT3B.

Isotype: IgG

Information d'application

Indications d'application: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C,-80 °C

Stockage commentaire: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Détails sur DNMT3B

Antigène: DNMT3B (DNA (Cytosine-5-)-Methyltransferase 3 beta (DNMT3B))

Autre désignation: DNMT3B

Sujet:

Background: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing By similarity. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Deloukas P., Nature 414:865-871(2001).
Li H., J. Biol. Chem. 281:19489-19500(2006).
Wijmenga C., Hum. Mutat. 16:509-517(2000).

Aliases: Cytosine 5methyltransferase 3B antibody, DNA antibody, DNA (cytosine 5) methyltransferase 3 beta antibody, DNA (cytosine 5)-methyltransferase 3B antibody, DNA (cytosine-5)-methyltransferase 3B antibody, DNA methyltransferase HsaIIIB antibody, DNA MTase HsaIIIB antibody, DNM3B_HUMAN antibody, Dnmt3b antibody, EC 2.1.1.37 antibody, ICF antibody, ICF1 antibody, M.HsaIIIB antibody, MGC124407 antibody, RP23-89H14.3 antibody

UniProt: Q9UBC3