CDK4 anticorps (AA 77-303)

N° du produit ABIN7193834

L’anticorps Souris Monoclonal anti-CDK4 a été validé pour ELISA, IHC, FACS et ICC. Il convient pour détecter CDK4 dans des échantillons de Humain.

Aperçu rapide pour CDK4 anticorps (AA 77-303) (ABIN7193834)

Antigène: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CDK4 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 4A11E2

Détail du produit anti-CDK4 anticorps

Épitope: AA 77-303

Fonction: CDK4 Antibody

Purification: Purified antibody

Immunogène: Purified recombinant fragment of human CDK4 (AA: 77-303) expressed in E. Coli.

Isotype: IgG1

Information d'application

Indications d'application:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Détails sur CDK4

Antigène: CDK4 (Cyclin-Dependent Kinase 4 (CDK4))

Autre désignation: CDK4

Sujet:

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Poids moléculaire: 33.7 kDa

UniProt: P11802

Pathways: Cycle Cellulaire, Mitotic G1-G1/S Phases, Regulation of Cell Size