BRCA1 anticorps (pSer1423)

N° du produit ABIN7224454

L’anticorps Lapin Polyclonal anti-BRCA1 a été validé pour WB, ELISA et IHC (p). Il convient pour détecter BRCA1 dans des échantillons de Humain et Rat.

Aperçu rapide pour BRCA1 anticorps (pSer1423) (ABIN7224454)

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-BRCA1 anticorps

Épitope: pSer1423

Fonction: BRCA1 (phospho Ser1423) Polyclonal Antibody

Specificité: Phospho-BRCA1 (S1423) Polyclonal Antibody detects endogenous levels of BRCA1 protein only when phosphorylated at S1423.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from human BRCA1 Phospho-Ser1423

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), IHC-P (1:100-1:300), ELISA (1:5000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur BRCA1

Antigène: BRCA1 (Breast Cancer 1 (BRCA1))

Autre désignation: BRCA1

Sujet: Rabbit Anti-BRCA1 (phospho Ser1423) Polyclonal Antibody,BRCA1, RNF53, Breast cancer type 1 susceptibility protein, RING finger protein 53,BRCA1 (BRCA1, DNA repair associated) encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in BRCA1 are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for BRCA1, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.,Breast cancer type 1 susceptibility protein

Poids moléculaire: observerd band 210kDa

ID gène: 672

UniProt: P38398

Pathways: Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus