BRCA2 anticorps (AA 1-80)

N° du produit ABIN7224500

L’anticorps anti-BRCA2 Polyclonal Lapin est utilisé pour la détection de BRCA2 dans des échantillons de Humain et Rat. Il a été validé pour ELISA, IHC et IF.

Aperçu rapide pour BRCA2 anticorps (AA 1-80) (ABIN7224500)

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BRCA2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-BRCA2 anticorps

Épitope: AA 1-80

Fonction: Rabbit Anti-BRCA2 Polyclonal Antibody

Specificité: BRCA2 Polyclonal Antibody detects endogenous levels of BRCA2 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the N-terminal region of human BRCA2 at AA range: 1-80

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:100-1:300,ELISA 1:20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur BRCA2

Antigène: BRCA2 (Breast Cancer 2, Early Onset (BRCA2))

Autre désignation: BRCA2

Sujet: BRCA2, FACD, FANCD1, Breast cancer type 2 susceptibility protein, Fanconi anemia group D1 proteinInherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.

ID gène: 675

UniProt: P51587

Pathways: Réparation de l'ADN, M Phase, Maintenance of Protein Location