CISH anticorps (AA 30-90)

N° du produit ABIN7227912

Cet anticorps anti-CISH Polyclonal Lapin (ABIN7227912) détecte spécifiquement CISH dans IHC, IF et ELISA. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CISH anticorps (AA 30-90) (ABIN7227912)

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CISH est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (IF), ELISA

Détail du produit anti-CISH anticorps

Épitope: AA 30-90

Fonction: Rabbit Anti-CIS Polyclonal Antibody

Specificité: The antibody detects endogenous levels of CIS

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from part region of human CIS protein at AA range: 30-90

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-200,ELISA 1:10000-20000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur CISH

Antigène: CISH (Cytokine Inducible SH2-Containing Protein (CISH))

Autre désignation: CIS

Sujet: Cytokine-inducible SH2-containing protein, CIS, CIS-1, Protein G18, Suppressor of cytokine signaling, SOCSThe protein encoded by CISH contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of CISH can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for CISH. CISH (Cytokine Inducible SH2 Containing Protein) is a Protein Coding gene. Diseases associated with CISH include Bacteremia and Malaria. Among its related pathways are Jak-STAT signaling pathway (KEGG) and IL-2 Signaling Pathway.

ID gène: 1154

UniProt: Q9NSE2

Pathways: Signalistation JAK/STAT, Response to Growth Hormone Stimulus