FGFR4 anticorps (pTyr642)

N° du produit ABIN7220534

Cet anticorps anti-FGFR4 est un anticorps Lapin Polyclonal détectant FGFR4 dans WB et ELISA. Adapté pour Humain, Rat et Souris.

Aperçu rapide pour FGFR4 anticorps (pTyr642) (ABIN7220534)

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FGFR4 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-FGFR4 anticorps

Épitope: pTyr642

Fonction: FGFR-4 (phospho Tyr642) Polyclonal Antibody

Specificité: Phospho-FGFR-4 (Y642) Polyclonal Antibody detects endogenous levels of FGFR-4 protein only when phosphorylated at Y642.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen

Immunogène: Synthesized peptide derived from human FGFR-4 Phospho-Tyr642

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:500-1:2000), ELISA (1:10000). Not yet tested in other applications.

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 50 % Glycerol, 0.5 % BSA and 0.02 % Sodium Azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur FGFR4

Antigène: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Autre désignation: FGFR-4

Sujet: Rabbit Anti-FGFR-4 (phospho Tyr642) Polyclonal Antibody,FGFR4, JTK2, TKF, Fibroblast growth factor receptor 4, FGFR-4, CD antigen CD334,The fibroblast growth factor receptor 4 encoded by FGFR4 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.,Fibroblast growth factor receptor 4

Poids moléculaire: observerd band 90kDa

ID gène: 2264

UniProt: P22455

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding