IDE anticorps

N° du produit ABIN7211960

Cet anticorps Souris Monoclonal détecte spécifiquement IDE dans WB, IF et IHC (p). Il présente une réactivité envers Humain.

Aperçu rapide pour IDE anticorps (ABIN7211960)

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IDE est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-IDE anticorps

Fonction: IDE Monoclonal Antibody

Specificité: The antibody detects endogenous IDE proteins.

Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen

Immunogène: Synthetic Peptide

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB (1:1000), IF (1:100-1:200), IHC-P (1:200).

Commentaires:

Primary Antibody

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, pH 7.4, containing 0.02 % Sodium Azide as preservative and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Détails sur IDE

Antigène: IDE (Insulin-Degrading Enzyme (IDE))

Autre désignation: IDE

Sujet: Mouse Anti-IDE Monoclonal Antibody,IDE, Insulin-degrading enzyme, Abeta-degrading protease, Insulin protease, Insulinase, Insulysin,IDE encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of insulin degrading enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in IDE have not been shown to be causitive for these diseases. Insulin degrading enzyme localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but have not been experimentally verified.,Insulin-degrading enzyme

Poids moléculaire: observerd band 118kDa

ID gène: 3416

UniProt: P14735

Pathways: SARS-CoV-2 Protein Interactome