MLH3 anticorps (AA 490-570)

N° du produit ABIN7221088

Cet anticorps Lapin Polyclonal détecte spécifiquement MLH3 dans WB, ELISA, IHC et IF. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MLH3 anticorps (AA 490-570) (ABIN7221088)

Antigène: MLH3 (MutL Homolog 3 (MLH3))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLH3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-MLH3 anticorps

Épitope: AA 490-570

Fonction: Rabbit Anti-MLH3 Polyclonal Antibody

Specificité: MLH3 Polyclonal Antibody detects endogenous levels of MLH3 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human MLH3 at AA range: 490-570

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur MLH3

Antigène: MLH3 (MutL Homolog 3 (MLH3))

Autre désignation: MLH3

Sujet: MLH3, DNA mismatch repair protein Mlh3, MutL protein homolog 3MLH3 is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The mutL homolog 3 encoded by MLH3 functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Poids moléculaire: 164kD

ID gène: 27030

UniProt: Q9UHC1

Pathways: Chromatin Binding