MLH3 anticorps (N-Term)

N° du produit ABIN7465777

Détail du produit anti-MLH3 anticorps

Antigène: MLH3 (MutL Homolog 3 (MLH3))

Épitope: N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MLH3 est non-conjugé

Application: Western Blotting (WB)

Réactivité croisée: Humain

Purification: Purified by antigen-affinity chromatography.

Immunogène: Recombinant protein encompassing a sequence within the N-terminus region of human MLH3. The exact sequence is proprietary.

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500-1:3000. Optimal dilutions/concentrations should be determined by the researcher. Not tested in other applications.

Commentaires:

Positive Control: HCT116

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.54 mg/mL

Buffer: 0.1M Tris-Glycine ( pH 7), 20 % Glycerol, 0.01 % Thimerosal

Agent conservateur: Thimerosal (Merthiolate)

Précaution d'utilisation: This product contains Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

Détails sur MLH3

Antigène: MLH3 (MutL Homolog 3 (MLH3))

Autre désignation: mutL homolog 3 (MLH3 Produits)

Synonymes: anticorps AV125803, anticorps BB126472, anticorps MGC80774, anticorps MLH3, anticorps HNPCC7, anticorps mutL homolog 3, anticorps mutL homolog 3 L homeolog, anticorps Mlh3, anticorps mlh3.L, anticorps MLH3, anticorps mlh3

Sujet: MutL homolog 3 , HNPCC7,This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq]

Poids moléculaire: 164 kDa

ID gène: 27030

UniProt: Q9UHC1

Pathways: Chromatin Binding