PFKL anticorps (AA 300-380)

N° du produit ABIN7216514

L’anticorps anti-PFKL Polyclonal Lapin est utilisé pour la détection de PFKL dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB, ELISA et IHC.

Aperçu rapide pour PFKL anticorps (AA 300-380) (ABIN7216514)

Antigène: PFKL (Phosphofructokinase, Liver (PFKL))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PFKL est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Détail du produit anti-PFKL anticorps

Épitope: AA 300-380

Fonction: Rabbit Anti-PFK-2 liv/tes Polyclonal Antibody

Specificité: PFK-2 liv/tes Polyclonal Antibody detects endogenous levels of PFK-2 liv/tes protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from the Internal region of human PFK-2 liv/tes at AA range: 300-380

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,IHC 1:50-300,ELISA 1:2000-20000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Date de péremption: 12 months

Détails sur PFKL

Antigène: PFKL (Phosphofructokinase, Liver (PFKL))

Autre désignation: PFK-2 liv/tes

Sujet: PFKFB1, F6PK, PFRX, 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase 1, 6PF-2-K/Fru-2,6-P2ase 1, PFK/FBPase 1, 6PF-2-K/Fru-2,6-P2ase liver isozyme, PFKFB4, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4, 6PF-2-K/Fru-2,6-P2ase 4,PFKFB1 encodes a member of the family of bifunctional 6-phosphofructo-2-kinase: fructose-2,6-biphosphatase enzymes. The enzyme forms a homodimer that catalyzes both the synthesis and degradation of fructose-2,6-biphosphate using independent catalytic domains. Fructose-2,6-biphosphate is an activator of the glycolysis pathway and an inhibitor of the gluconeogenesis pathway. Consequently, regulating fructose-2,6-biphosphate levels through the activity of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 is thought to regulate glucose homeostasis. Multiple alternatively spliced transcript variants have been found for PFKFB1.

Poids moléculaire: 54kD

ID gène: 5207, 5210

UniProt: P16118, Q16877

Pathways: Negative Regulation of Hormone Secretion, L'effet Warburg