HYOU1 anticorps

N° du produit ABIN7232796

Cet anticorps anti-HYOU1 est un anticorps Souris Monoclonal détectant HYOU1 dans WB et ELISA. Adapté pour Humain.

Aperçu rapide pour HYOU1 anticorps (ABIN7232796)

Antigène: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HYOU1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: 6E3-2C3

Détail du produit anti-HYOU1 anticorps

Fonction: Anti-Grp170 Mouse Monoclonal Antibody

Specificité: This antibody recognizes human, mouse, and rat Grp170 (170 kDa).

Réactivité croisée: Humain, Souris, Rat

Purification: Purified by Protein G affinity chromatography

Immunogène: Synthetic peptide sequence derived from human Grp170 (accession no. NP_006389.3)

Isotype: IgG2b

Information d'application

Indications d'application: ELISA: confirmed with antibody (1-10 μg/mL) binding to Grp170 at 5 μg/mL on the solid phase
Immunoblotting: with antibody at 1.0-2.0 μg/mL. A band of 170 kDa is detected.
These are recommended concentrations
End user should determine optimal concentrations for their applications.
Positive control: HEK293 cell lysate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Reconstitution: Dilute in PBS or medium that is identical to that used in the assay system.

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, 0.1 % sodium azide, 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: This antibody is stable for at least one (1) year at -20°C.

Détails sur HYOU1

Antigène: HYOU1 (Hypoxia Up Regulated 1 (HYOU1))

Autre désignation: HYOU1

Sujet: Hypoxia up-regulated protein 1,Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding. {PubMed:10037731}.,Grp170 is a major chaperone/stress protein resident in the ER. It is distantly related in sequence to both hsp110 and hsp70 families, but represents the Grp170 stress protein family. Studies have suggested that Grp170 is an important element of the protein processing machinery of the ER. Unlike Hsp110 and Hsp70, Grp170 has two distinct chaperoning domains, a classic beta-sheet peptide binding domain, with some COOH- terminal sequence, and a COOH-terminal alpha-helical domain. Like other members of the Hsp70 superfamily, Grp170 can elicit anti-tumor immune responses most likely by chaperoning antigenic peptide and binding to receptor(s) on antigen-presenting cells (APC).,Endoplasmic reticulum lumen.,150 kDa oxygen-regulated protein, ORP-150, 170 kDa glucose-regulated protein, GRP-170

NCBI Accession: NP_006389

UniProt: Q9Y4L1

Pathways: ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome