alpha 2 Macroglobulin anticorps (AA 1155-1474)

N° du produit ABIN7265559

Cet anticorps anti-alpha 2 Macroglobulin est un anticorps Lapin Polyclonal détectant alpha 2 Macroglobulin dans WB et IHC. Adapté pour Humain.

Aperçu rapide pour alpha 2 Macroglobulin anticorps (AA 1155-1474) (ABIN7265559)

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp alpha 2 Macroglobulin est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-alpha 2 Macroglobulin anticorps

Épitope: AA 1155-1474

Fonction: Alpha-2-Macroglobulin (A2M) Rabbit pAb

Séquence: ALAGNQDKRK EVLKSLNEEA VKKDNSVHWE RPQKPKAPVG HFYEPQAPSA EVEMTSYVLL AYLTAQPAPT SEDLTSATNI VKWITKQQNA QGGFSSTQDT VVALHALSKY GAATFTRTGK AAQVTIQSSG TFSSKFQVDN NNRLLLQQVS LPELPGEYSM KVTGEGCVYL QTSLKYNILP EKEEFPFALG VQTLPQTCDE PKAHTSFQIS LSVSYTGSRS ASNMAIVDVK MVSGFIPLKP TVKMLERSNH VSRTEVSSNH VLIYLDKVSN QTLSLFFTVL QDVPVRDLKP AIVKVYDYYE TDEFAIAEYN APCSKDLGNA

Réactivité croisée: Humain

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 1155-1474 of human Alpha-2-Macroglobulin (Alpha-2-Macroglobulin (A2M)) (NP_000005.2).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur alpha 2 Macroglobulin

Antigène: alpha 2 Macroglobulin (A2M) (alpha-2-Macroglobulin (A2M))

Autre désignation: A2M

Sujet: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.,A2M;A2MD;CPAMD5;FWP007;S863-7,Cell Biology & Developmental Biology,Ubiquitin,Cardiovascular,Blood,Serum Proteins,A2M

Poids moléculaire: 163kDa

ID gène: 2

UniProt: P01023

Pathways: Lipid Metabolism