Cyclin E1 anticorps (AA 300-410)

N° du produit ABIN7266565

Cet anticorps Lapin Polyclonal détecte spécifiquement Cyclin E1 dans WB et IHC. Il présente une réactivité envers Humain.

Aperçu rapide pour Cyclin E1 anticorps (AA 300-410) (ABIN7266565)

Antigène: Cyclin E1 (CCNE1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Cyclin E1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Cyclin E1 anticorps

Épitope: AA 300-410

Fonction: Cyclin E1 Rabbit pAb

Séquence: AASALYHFSS SELMQKVSGY QWCDIENCVK WMVPFAMVIR ETGSSKLKHF RGVADEDAHN IQTHRDSLDL LDKARAKKAM LSEQNRASPL PSGLLTPPQS GKKQSSGPEM A

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Polyclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant fusion protein containing a sequence corresponding to amino acids 300-410 of human Cyclin E1 (NP_001229.1).

Isotype: IgG

Information d'application

Indications d'application: WB,1:500 - 1:2000,IHC,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Cyclin E1

Antigène: Cyclin E1 (CCNE1)

Autre désignation: CCNE1

Sujet: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB.,CCNE1,CCNE,pCCNE1,cyclin E1,Epigenetics & Nuclear Signaling,Cancer,Cell Biology & Developmental Biology,Cell Cycle,Centrosome,Cyclins,G1/S Checkpoint,Hedgehog Signaling Pathway,CCNE1

Poids moléculaire: 47kDa

ID gène: 898

UniProt: P24864

Pathways: Cycle Cellulaire, Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Mitotic G1-G1/S Phases