Lamin A/C anticorps

N° du produit ABIN7268177

L’anticorps Lapin Monoclonal anti-Lamin A/C a été validé pour WB, IHC, IF et IP. Il convient pour détecter Lamin A/C dans des échantillons de Humain.

Aperçu rapide pour Lamin A/C anticorps (ABIN7268177)

Antigène: Lamin A/C (LMNA)

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Lamin A/C est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Classe de qualité: KO Validated

Détail du produit anti-Lamin A/C anticorps

Fonction: [KO Validated] Lamin A/C Rabbit mAb

Réactivité croisée: Humain, Souris, Rat

Attributs du produit: Monoclonal Antibodies

Purification: Affinity purification

Immunogène: Recombinant protein of human Lamin A/C.

Isotype: IgG

Information d'application

Indications d'application: WB,1:50000 - 1:200000,IHC,1:50 - 1:1000,IF,1:50 - 1:1000,IP,1:50 - 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C. Avoid freeze / thaw cycles.

Détails sur Lamin A/C

Antigène: Lamin A/C (LMNA)

Autre désignation: LMNA

Sujet: The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.,LMNA,CDCD1,CDDC,CMD1A,CMT2B1,EMD2,FPL,FPLD,FPLD2,HGPS,IDC,LDP1,LFP,LGMD1B,LMN1,LMNC,LMNL1,MADA,PRO1,lamin,Lamin A/C,Apoptosis,Cell Biology & Developmental Biology,Cell Cycle,Cytoskeleton,Cytoskeleton_Intermediate Filaments,Death Receptor Signaling Pathway,PI3K-Akt Signaling Pathway,Protein folding,Protein phosphorylation,Signal Transduction,Stem Cells,LMNA

Poids moléculaire: 62-74kDa

ID gène: 4000

UniProt: P02545

Pathways: Apoptose, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus