ErbB2/Her2 anticorps (C-Term)

N° du produit ABIN7448962

Cet anticorps Lapin Polyclonal détecte spécifiquement ErbB2/Her2 dans IHC et IF (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ErbB2/Her2 anticorps (C-Term) (ABIN7448962)

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ErbB2/Her2 est non-conjugé

Application: Immunohistochemistry (IHC), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Détail du produit anti-ErbB2/Her2 anticorps

Épitope: C-Term

Fonction: Rabbit anti-ErbB2 IHC Antibody, Affinity Purified

Homologie: Mouse,Rat,Dog,Horse,Rabbit,Pig,Golden hamster,Panda,Cat,Orangutan,Monkey,Gorilla,Chimpanzee,American black bear,White-tufted-ear marmoset,Small-eared galago,Naked mole rat,Chinese hamster,Crab-eating macaque,Thirteen-lined ground squirrel,Northern white-cheeked gibbon

Purification: Affinity Purified

Immunogène: Between AA 1200 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC-IF: 1:50 - 1:500

IHC: 1:100 - 1:500

Restrictions: For Research Use only

Stockage

Concentration: 250 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ErbB2/Her2

Antigène: ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))

Autre désignation: ErbB2

Sujet: Background: ErbB2 is a member of the receptor tyrosine kinase family of proteins. The four members of this family are ErbB1 (Epidermal growth factor receptor, EGFR/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). The ErbB receptor members are single-pass transmembrane proteins with an extracellular ligand-binding domain and a cytoplasmic tyrosine-kinase domain. The epidermal growth factor (EGF) and its related proteins serve as the ligands for the ErbB receptors. Upon binding, the receptors heterodimerize, autophosphorylate and make contact with adapter molecules to transmit cellular signals involved in cell proliferation, survival, and differentiation. The ErbB2 receptor is the only member that does not interact with a ligand, but instead functions as a heterodimeric partner to coordinate signals from other ligand bound ErbB receptors. Amplification and/or overexpression of ErbB2 have been reported in many cancers.

ID gène: 2064

NCBI Accession: NP_004439

UniProt: P04626

Pathways: Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development