BRCA1 anticorps (AA 700-750)
Aperçu rapide pour BRCA1 anticorps (AA 700-750) (ABIN7449153)
Antigène
Voir toutes BRCA1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 700-750
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Fonction
- Rabbit anti-BRCA1 Antibody, Affinity Purified
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Homologie
- Gorilla,Chimpanzee
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Purification
- Affinity Purified
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Immunogène
- between AA 700 and 750
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Isotype
- IgG
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Indications d'application
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IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
IP: 2 - 10 μg/mg lysate
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Restrictions
- For Research Use only
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Concentration
- 1000 μg/mL
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Buffer
- Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C
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Date de péremption
- 12 months
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- BRCA1 (Breast Cancer 1 (BRCA1))
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Autre désignation
- BRCA1
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Sujet
- Background: BRCA1 was identified as a gene with germline mutations that predisposes women to breast and ovarian cancer. The BRCA1 tumor suppressor is a large protein that has been demonstrated to interact with a multitude of proteins involved in the DNA damage response and cell cycle checkpoints to maintain genomic integrity. BRCA1 functions by regulating the activities of its interacting proteins which mediate processes such as gene transcription, gene repression, protein phosphorylation, and ubiquitination.
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ID gène
- 672
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NCBI Accession
- NP_009225
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UniProt
- P38398
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Pathways
- Cycle Cellulaire, Réparation de l'ADN, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
Antigène
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