DIS3L2 anticorps (AA 475-525)

N° du produit ABIN7449190

Cet anticorps Lapin Polyclonal détecte spécifiquement DIS3L2 dans WB. Il présente une réactivité envers Humain.

Aperçu rapide pour DIS3L2 anticorps (AA 475-525) (ABIN7449190)

Antigène: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIS3L2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-DIS3L2 anticorps

Épitope: AA 475-525

Fonction: Rabbit anti-DIS3L2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 475 and 525

Isotype: IgG

Information d'application

Indications d'application: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur DIS3L2

Antigène: DIS3L2 (DIS3-Like Exonuclease 2 (DIS3L2))

Autre désignation: DIS3L2

Sujet: Background: DIS3L2 is a 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation. [taken from the Universal Protein Resource (UniProt) Q8IYB7].

ID gène: 129563

UniProt: Q8IYB7

Pathways: Stem Cell Maintenance