EGLN1 anticorps (AA 1-50)

N° du produit ABIN7451016

Cet anticorps anti-EGLN1 Polyclonal Lapin (ABIN7451016) détecte spécifiquement EGLN1 dans WB et IP. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour EGLN1 anticorps (AA 1-50) (ABIN7451016)

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGLN1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-EGLN1 anticorps

Épitope: AA 1-50

Fonction: Rabbit anti-PHD2 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1 and 50

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 10 μg/mg lysate

WB: 1:500 - 1:2,500

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur EGLN1

Antigène: EGLN1 (Egl-9 Family Hypoxia Inducible Factor 1 (EGLN1))

Autre désignation: PHD2

Sujet: Background: PHD2 is one of 4 PHD (PHD1-4) enzymes that function as oxygen sensors and are responsible for the post-translational modification of HIF-1alpha, a component of a transcriptional complex involved in oxygen homeostasis. During normoxic levels, PHDs catalyze the hydroxylation of prolyl residues on HIF-1alpha and target it for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The PHD isoforms appear to function in a non-redundant manner and may differ in their expression patterns and their catalytic selectivity.

ID gène: 54583

NCBI Accession: NP_071334

UniProt: Q9GZT9

Pathways: cAMP Metabolic Process, L'effet Warburg