Exonuclease 1 anticorps (AA 725-775)

N° du produit ABIN7452756

Cet anticorps anti-Exonuclease 1 est un anticorps Lapin Polyclonal détectant Exonuclease 1 dans WB et IP. Adapté pour Humain.

Aperçu rapide pour Exonuclease 1 anticorps (AA 725-775) (ABIN7452756)

Antigène: Exonuclease 1 (EXO1)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Exonuclease 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-Exonuclease 1 anticorps

Épitope: AA 725-775

Fonction: Rabbit anti-Exonuclease 1 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 725 and 775

Isotype: IgG

Information d'application

Indications d'application:

IP: 5 - 15 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Exonuclease 1

Antigène: Exonuclease 1 (EXO1)

Autre désignation: Exonuclease 1

Sujet: Background: Exonuclease 1 is a 5'-3' double-stranded DNA exonuclease which may also possess a cryptic 3'-5' double-stranded DNA exonuclease activity. Exonuclease 1 functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. It also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Exonuclease 1 is required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes and is essential for male and female meiosis [taken from the Universal Protein Resource (UniProt) Q9UQ84].

ID gène: 9156

NCBI Accession: NP_006018

UniProt: Q9UQ84

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response