MAPKAP1 anticorps (C-Term)

N° du produit ABIN7453487

Détail du produit anti-MAPKAP1 anticorps

Antigène: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Épitope: C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAPKAP1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Fonction: Rabbit anti-Sin1 Antibody, Affinity Purified

Homologie: Mouse,Rat,Chicken,Sheep,Bovine,Orangutan

Purification: Affinity Purified

Immunogène: between AA 470 and C-term

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:1,000 - 1:5,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur MAPKAP1

Antigène: MAPKAP1 (Mitogen-Activated Protein Kinase Associated Protein 1 (MAPKAP1))

Autre désignation: Sin1 (MAPKAP1 Produits)

Synonymes: anticorps CG10105, anticorps Dmel\\CG10105, anticorps dSin1, anticorps sin1, anticorps MAPKAP1, anticorps im:7143088, anticorps si:ch73-242f23.1, anticorps mip1, anticorps sin1b, anticorps sin1g, anticorps MGC53034, anticorps JC310, anticorps MIP1, anticorps SIN1, anticorps SIN1b, anticorps SIN1g, anticorps AI591529, anticorps D230039K05Rik, anticorps Sin1, anticorps SAPK-interacting protein 1, anticorps mitogen-activated protein kinase associated protein 1, anticorps mitogen-activated protein kinase associated protein 1 L homeolog, anticorps Sin1, anticorps MAPKAP1, anticorps mapkap1, anticorps Mapkap1, anticorps mapkap1.L

Sujet: Background: Stress-activated map kinase-interacting protein 1 (Sin1) is highly similar to the yeast stress- activated protein kinase SIN1. Sin1 is an essential mTORC2 subunit that is required to act as the PDK2 that phosphorylates Akt/PKB at Ser 473. Sin1 has been implicated as a scaffolding protein. Sin1 is required for rictor binding in the mTORC2 complex. Sin1 has also been shown to be important to the SAPK (stress-activated kinase) signaling pathway and in the nucleus may act as a scaffold between ATF-2 and p38 to facilitate p38-induced phosphorylation of ATF-2. Sin1 is also found to form a complex with c-Jun N-terminal kinase (JNK) and may similarly function as a scaffolding protein in JNK signaling.

ID gène: 79109

NCBI Accession: NP_001006618

UniProt: Q9BPZ7

Pathways: Signalisation PI3K-Akt, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development, CXCR4-mediated Signaling Events