GRB10 anticorps (AA 100-150)

N° du produit ABIN7454420

Cet anticorps anti-GRB10 Polyclonal Lapin (ABIN7454420) détecte spécifiquement GRB10 dans IP et IHC (fp). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour GRB10 anticorps (AA 100-150) (ABIN7454420)

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GRB10 est non-conjugé

Application: Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-GRB10 anticorps

Épitope: AA 100-150

Fonction: Rabbit anti-GRB10 Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 100 and 150

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: Not recommended. Use rabbit anti-GRB10 antibody A301-734A.

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur GRB10

Antigène: GRB10 (Growth Factor Receptor-Bound Protein 10 (GRB10))

Autre désignation: GRB10

Sujet: Background: Growth factor receptor-bound protein 10 (GRB10) is a member of a family of adaptor proteins that bind to a variety of growth factor receptors to regulate receptor signaling and mediate signals for a variety of processes such as metabolism, growth, apoptosis, and migration. As a dimer, via its BPS (between PH and SH2) and SH2 (src-homology 2) domains, GRB10 associates with the insulin receptor (IR) as well as the insulin-like growth factor receptor (IGFR). GRB10's association with the IR has been shown to have inhibitory effects on insulin-induced kinase signaling, however studies have also reported that GRB10 can also have positive effects on IR signaling. It is suggested that GRB10 can serve in cellular functions independent of an interaction with the IR.

ID gène: 2887

NCBI Accession: NP_005302

UniProt: Q13322

Pathways: Regulation of Carbohydrate Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2