CDC20 anticorps (AA 449-499)

N° du produit ABIN7454724

Cet anticorps Lapin Polyclonal détecte spécifiquement CDC20 dans WB, IP et IHC (fp). Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour CDC20 anticorps (AA 449-499) (ABIN7454724)

Antigène: CDC20 (Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDC20 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-CDC20 anticorps

Épitope: AA 449-499

Fonction: Rabbit anti-CDC20 Antibody, Affinity Purified

Homologie: Pig

Purification: Affinity Purified

Immunogène: between AA 449 and 499

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur CDC20

Antigène: CDC20 (Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20))

Autre désignation: CDC20

Sujet: Background: CDC20 is a WD repeat containing cell cycle-regulator that binds to and activates the ubiquitin-ligase activity of the APC/c (anaphase-promoting complex/cyclosome). APC/c ubiquitinating activity is responsible for the degradation of securin and cyclin B that prompts the onset of anaphase and exit from mitosis. CDC20 has also been reported to form a complex with histone deacetylases and can function as a transcriptional repressor involved in cell cycle arrest. As a regulator of APC/c activity, CDC20 plays a key role in the spindle-assembly checkpoint.

ID gène: 991

NCBI Accession: NP_001246

UniProt: Q12834