14-3-3 sigma/SFN anticorps (AA 198-248)

N° du produit ABIN7454767

L’anticorps Lapin Polyclonal anti-14-3-3 sigma/SFN a été validé pour WB, IP et IHC (fp). Il convient pour détecter 14-3-3 sigma/SFN dans des échantillons de Humain.

Aperçu rapide pour 14-3-3 sigma/SFN anticorps (AA 198-248) (ABIN7454767)

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp 14-3-3 sigma/SFN est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-14-3-3 sigma/SFN anticorps

Épitope: AA 198-248

Fonction: Rabbit anti-14-3-3 Sigma Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 198 and 248

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:2,000 to 1:10,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:10,000 - 1:25,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur 14-3-3 sigma/SFN

Antigène: 14-3-3 sigma/SFN (SFN) (Stratifin (SFN))

Autre désignation: 14-3-3 Sigma

Sujet: Background: 14-3-3 sigma was identified as an epithelial cell marker. It is part of the 14-3-3 family of proteins in which seven isoforms have been identified: beta, zeta, gamma, eta, epsilon, tau, and sigma. 14-3-3 proteins function as adaptors that bind with a number of partners to mediate various signaling pathways. 14-3-3 sigma is also called stratifin or HME1 and appears to function as a tumor suppressor whose expression can be downregulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.

ID gène: 2810

NCBI Accession: NP_006133

UniProt: P31947

Pathways: Signalisation p53, Myometrial Relaxation and Contraction