TDG anticorps (AA 360-410)

N° du produit ABIN7455026

Cet anticorps anti-TDG est un anticorps Lapin Polyclonal détectant TDG dans WB, IP et IHC (fp). Adapté pour Humain.

Aperçu rapide pour TDG anticorps (AA 360-410) (ABIN7455026)

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TDG est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-TDG anticorps

Épitope: AA 360-410

Fonction: Rabbit anti-TDG Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: Between AA 360 and 410

Isotype: IgG

Information d'application

Indications d'application:

IHC: 1:500 - 1:2,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 10 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur TDG

Antigène: TDG (Thymine-DNA Glycosylase (TDG))

Autre désignation: TDG

Sujet: Background: Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine [taken from NCBI Entrez Gene (Gene ID: 6996)].

ID gène: 6996

NCBI Accession: NP_003202

UniProt: Q13569

Pathways: Réparation de l'ADN, Chromatin Binding