ABL1 anticorps (AA 550-600)

N° du produit ABIN7455216

Cet anticorps Lapin Polyclonal détecte spécifiquement ABL1 dans WB, IP, IF/ICC et IHC (fp). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour ABL1 anticorps (AA 550-600) (ABIN7455216)

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ABL1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (fixed cells) (IF/ICC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Détail du produit anti-ABL1 anticorps

Épitope: AA 550-600

Fonction: Rabbit anti-cAbl Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 550 and 600

Isotype: IgG

Information d'application

Indications d'application:

ICC-IF: 1:100 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE cell sections. For cytospin preparations of formaldehyde fixed cells permeabilization with Triton-X 100 is recommended.

IHC: 1:100 - 1:1,000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 200 μg/mL

Buffer: Tris-buffered Saline containing 0.1 % BSA and 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur ABL1

Antigène: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Autre désignation: cAbl

Sujet: Background: c-Abl is the human cellular homolog of a the v-Abl viral oncogene. v-Abl was originally discovered as a mouse cell-derived sequence in the genome of the Abelson murine leukemia virus (A-MuLV), a transforming retrovirus isolated by the laboratory of Dr. H.T. Abelson. c-Abl is a tyrosine kinase from the Src-family of tyrosine kinases that localizes to both the cytoplasm and nucleus. It bears an SH2 (src-homology 2) and SH3 (src-homology 3) domain responsible for mediating c-Abl protein-protein interactions. c-Abl is implicated to play a role in multiple cellular processes such as cell cycle checkpoint signaling, apoptosis, cell differentiation, cell adhesion, and transcriptional regulation. Chromosomal translocations involving the c-Abl gene are associated with human leukemias.

ID gène: 25

NCBI Accession: NP_005148

UniProt: P00519

Pathways: Apoptose, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism