PD-L1 anticorps

N° du produit ABIN7457963

Cet anticorps anti-PD-L1 est un anticorps Souris Monoclonal détectant PD-L1 dans FACS, Func et BR. Adapté pour Humain.

Aperçu rapide pour PD-L1 anticorps (ABIN7457963)

Antigène: PD-L1 (CD274 (PD-L1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PD-L1 est non-conjugé

Application: Flow Cytometry (FACS), Functional Studies (Func), Blocking Reagent (BR)

Clone: 29E-2A3

Détail du produit anti-PD-L1 anticorps

Purification: Purified

Stérilité: 0.2 μm filtered

niveau d'endotoxine: Low Endotoxin: Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

Matching Isotype Control: AF/LE Purified Mouse IgG2b, κ Isotype Control (ABIN7469801)

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE)

Agent conservateur: Azide free

Stock: 4 °C

Stockage commentaire: Store at 2~8°C. Do not freeze.

Détails sur PD-L1

Antigène: PD-L1 (CD274 (PD-L1))

Autre désignation: PD-L1

Sujet: B7-H1, PD-L1,Programmed cell death ligand 1,B7 homolog 1,B7-H, B7H1, PDL1, PDCD1L1, PDCD1LG1,CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells.

ID gène: 29126

UniProt: Q9NZQ7

Pathways: Cancer Immune Checkpoints