NLRP3 anticorps (Biotin)

N° du produit ABIN719488

Cet anticorps Lapin Polyclonal détecte spécifiquement NLRP3 dans IHC (p). Il présente une réactivité envers Humain, Souris, Rat et Chien.

Aperçu rapide pour NLRP3 anticorps (Biotin) (ABIN719488)

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Reactivité: Humain, Souris, Rat, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP3 est conjugé à/à la Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-NLRP3 anticorps (Biotin)

Réactivité croisée: Chien, Humain, Souris, Rat

Purification: Purified by Protein A.

Immunogène: KLH conjugated synthetic peptide derived from human Cryopyrin

Isotype: IgG

Information d'application

Indications d'application: WB(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C for 12 months.

Date de péremption: 12 months

Détails sur NLRP3

Antigène: NLRP3 (NLR Family, Pyrin Domain Containing 3 (NLRP3))

Autre désignation: Cryopyrin

Sujet:

Synonyms: NACHT, LRR and PYD domains-containing protein 3, Angiotensin/vasopressin receptor AII/AVP-like, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, PYRIN-containing APAF1-like protein 1, NLRP3, C1orf7, CIAS1, NALP3, PYPAF1

Background: May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.

Poids moléculaire: 118kDa

ID gène: 114548

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Endopeptidase Activity, Inflammasome