Recombinant CD3 anticorps

N° du produit ABIN7488633

L’anticorps anti-CD3 Monoclonal Souris est utilisé pour la détection de CD3 dans des échantillons de Humain. Il a été validé pour FACS.

Aperçu rapide pour Recombinant CD3 anticorps (ABIN7488633)

Antigène: CD3

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD3 est non-conjugé

Application: Flow Cytometry (FACS)

Clone: SP34-2

Détail du produit anti-CD3 anticorps

Fonction: Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2)

Immunogène: Monoclonal Anti-Human CD3 Antibody, Mouse IgG1 (SP34-2) is a monoclonal antibody recombinantly expressed from human 293 cells (HEK293). The mouse monoclonal antibody is produced from a hybridoma resulting from fusion of SP2/0 myeloma and B-lymphocytes obtained from a mouse immunized with CD3.

Isotype: IgG1

Information d'application

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Stock: -20 °C

Détails sur CD3

Antigène: CD3

Autre désignation: CD3

Sujet: CD3e molecule, epsilon is also known as CD3E, is a T-cell surface single-pass type I membrane glycoprotein. CD3E contains 1 Ig-like (immunoglobulin-like) domain and 1 ITAM domain. CD3E, together with CD3-gamma, CD3-delta and CD3-zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. CD3E plays an essential role in T-cell development, and defects in CD3E gene cause severe immunodeficiency. CD3E gene has also been linked to a susceptibility to type I diabetes in women. CD3E has been shown to interact with TOP2B, CD3EAP and NCK2.

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway