Recombinant CD86 anticorps

N° du produit ABIN7543020

L’anticorps Souris Monoclonal anti-CD86 a été validé pour FACS et IF. Il convient pour détecter CD86 dans des échantillons de Rat.

Aperçu rapide pour Recombinant CD86 anticorps (ABIN7543020)

Antigène: CD86

Type d'anticorp: Recombinant Antibody

Reactivité: Rat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD86 est non-conjugé

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: OX-48

Détail du produit anti-CD86 anticorps

Fonction: Anti-CD86 [OX-48], Mouse IgG1, kappa

Specificité: OX-48 binds specifically to CD86 targets which are present on subsets of T and B blasts, spleen macrophages and polymorphs, peritoneal macrophages, dendritic cells. OX48 does not appear to bind the same epitope of CD86 as 24F (Stephens et al. 2004). CD86 is expressed at high levels on resting peripheral monocytes and dendritic cells and at very low density on resting B and T lymphocytes - expression is rapidly upregulated by B cell specific stimuli. CD86 acts as a ligand for CD28 and CTLA-4. CD86 works in tandem with CD80 to prime T cells. 2 splice isoforms exist.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: OX-48 was prepared by immunizing mice with activated rat T cell blasts

Isotype: IgG1 kappa

Information d'application

Indications d'application: OX-48 blocks IL-2 production and proliferation of T cells (except when in exponential phase) (Samoza et al. 1990). The antibody can also be used for FC (Stephens et al. 2004), FACS and IPs. Ox-48 has been shown to be able to block binding of CD86 with its ligand CD28.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD86

Antigène: CD86

Autre désignation: CD86

Sujet: B72, B-72, OX48, MRC OX-48, MRC OX48

UniProt: Q62810

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation