Recombinant Mesothelin anticorps

N° du produit ABIN7543231

Cet anticorps anti-Mesothelin Monoclonal Human (Clone MOR06626) (ABIN7543231) détecte spécifiquement Mesothelin dans ELISA et FACS. L’anticorps est réactif avec des échantillons de Humain et Souris.

Aperçu rapide pour Recombinant Mesothelin anticorps (ABIN7543231)

Antigène: Mesothelin (MSLN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris

Hôte: Human

Clonalité: Monoclonal

Conjugué: Cet anticorp Mesothelin est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: MOR06626

Détail du produit anti-Mesothelin anticorps

Fonction: Anti-Mesothelin [MOR06626], Human IgG1, kappa

Specificité:

This antibody binds the human and murine mesothelin. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. Because of its limited expression in normal tissues and overexpression in tumors, mesothelin is a promising candidate for tumor-specific therapy.

Application Notes original Clone: The binding reactivity of the Fab version of this antibody towards human and murine mesothelin was done using ELISA. The Fab version of this antibody binds human and murine meosthelin with a binding affinity of Kd= 6.7 x 10-10 and Kd= 6.7 x 10-9 (US9023351). The IgG1 version of this antibody was used to detect mesothelin on NCI-H226 cells by flow cytometry (US9023351).

Réactivité croisée: Souris

Purification: Protein A affinity purified

Immunogène: The original antibody was isolated from a synthetic phage display library (HuCAL®) after 3 rounds of panning against whole CHO-A9 and NCI-H226 cells expressing mesothelin.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

OriginalSpeciesName: Human

OriginalFormat: IgG1

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Mesothelin

Antigène: Mesothelin (MSLN)

Autre désignation: Mesothelin

Sujet: MSLN, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process