Recombinant Mesothelin anticorps

N° du produit ABIN7543232

Cet anticorps Lapin Chimeric détecte spécifiquement Mesothelin dans ELISA et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant Mesothelin anticorps (ABIN7543232)

Antigène: Mesothelin (MSLN)

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp Mesothelin est non-conjugé

Application: ELISA, Flow Cytometry (FACS)

Clone: MOR06626

Détail du produit anti-Mesothelin anticorps

Fonction: Anti-Mesothelin [MOR06626], Rabbit IgG, kappa

Specificité: This antibody binds the human and murine mesothelin. Mesothelin is a differentiation antigen present on normal mesothelial cells and overexpressed in several human tumors, including mesothelioma and ovarian and pancreatic adenocarcinoma. Because of its limited expression in normal tissues and overexpression in tumors, mesothelin is a promising candidate for tumor-specific therapy.

Réactivité croisée: Souris

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was isolated from a synthetic phage display library (HuCAL®) after 3 rounds of panning against whole CHO-A9 and NCI-H226 cells expressing mesothelin.

Isotype: IgG kappa

Information d'application

Indications d'application: The binding reactivity of the Fab version of this antibody towards human and murine mesothelin was done using ELISA. The Fab version of this antibody binds human and murine meosthelin with a binding affinity of Kd= 6.7 x 10-10 and Kd= 6.7 x 10-9 (US9023351). The IgG1 version of this antibody was used to detect mesothelin on NCI-H226 cells by flow cytometry (US9023351).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur Mesothelin

Antigène: Mesothelin (MSLN)

Autre désignation: Mesothelin

Sujet: MSLN, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

UniProt: Q13421

Pathways: EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process