Recombinant CD47 anticorps (Extracellular Domain)

N° du produit ABIN7543262

Cet anticorps Lapin Chimeric détecte spécifiquement CD47 dans FACS et ELISA. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant CD47 anticorps (Extracellular Domain) (ABIN7543262)

Antigène: CD47

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp CD47 est non-conjugé

Application: Flow Cytometry (FACS), ELISA

Clone: 2D14

Détail du produit anti-CD47 anticorps

Épitope: Extracellular Domain

Fonction: Anti-CD47 [2D14], Rabbit IgG, kappa

Specificité: This antibody binds the extracellular domain of the human CD47, which is broadly distributed on normal adult tissues, as well as ovarian tumors, and is especially abundant in some epithelia and the brain. IAP or integrin assocaited protein has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It further plays an important role in memory formation and synaptic plasticity in the hippocampus. It also acts as a receptor for SIRPA. Binding to SIRPA prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing BALB/c mice with recombinant human CD47 extracellular domain with equal volume of adjuvant as an immunogen.

Isotype: IgG kappa

Information d'application

Indications d'application: The binding specificity of this antibody for recombinant human CD47 was done using ELISA. This antibody is capable of detecting CD47 expressed on the cell surface of K562 (human chronic myeloid leukemia cells) in a flow cytometry (CN110066336).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD47

Antigène: CD47

Autre désignation: CD47

Sujet: IAP, MER6, OV-3, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein, Protein MER6, ovarian cancer marker

UniProt: Q08722