Recombinant CD3 anticorps

N° du produit ABIN7543308

L’anticorps Lapin Chimeric anti-CD3 a été validé pour FACS et in vitro. Il convient pour détecter CD3 dans des échantillons de Humain.

Aperçu rapide pour Recombinant CD3 anticorps (ABIN7543308)

Antigène: CD3

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp CD3 est non-conjugé

Application: Flow Cytometry (FACS), In vitro Assay (in vitro)

Clone: CD3B219

Détail du produit anti-CD3 anticorps

Fonction: Anti-CD3 [CD3B219], Rabbit IgG, lambda

Specificité: The antibody is specific for CD3 epsilon.

Réactivité croisée: Singe

Attributs du produit:

Original Species of Ab: Human

Original Format of Ab: IgG4

Purification: Protein A affinity purified

Isotype: IgG lambda

Information d'application

Indications d'application: The antibody was used to construct different CD33 xCD3 bispecific antibodies (IgG4). In vitro T cell mediated cytotoxicity assays were performed using the bispecific antibody and the cytotoxicity was measured by flow cytometry. Ex vivo cytotoxicity assay showed the paired antibody promoted a dose-dependent reduction of total cytotoxicity that correlated with T cell activation after 48 hours (US20210040209A1). The antibody is considered a high affinity binder (Kd= 8 mM) (US20210214440A1). The CD33xCD3 bispecific antibodies specifically induce cell cytotoxicity of MOLM-13 cells and CD33+ monocytes at 48 hr (US20200048349A1).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur CD3

Antigène: CD3

Autre désignation: CD3

Sujet: T-cell surface glycoprotein CD3 epsilon chain, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, SP34-2

UniProt: P07766

Pathways: TCR Signaling, Ubiquitin Proteasome Pathway