Recombinant FcRn anticorps

N° du produit ABIN7543364

Cet anticorps Lapin Chimeric détecte spécifiquement FcRn dans BP, in vitro et in vivo. Il présente une réactivité envers Humain.

Aperçu rapide pour Recombinant FcRn anticorps (ABIN7543364)

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Chimeric

Conjugué: Cet anticorp FcRn est non-conjugé

Application: Blocking Peptide (BP), In vitro Assay (in vitro), In vivo Studies (in vivo)

Clone: H22-0015

Détail du produit anti-FcRn anticorps

Fonction: Anti-FcRn [h22-0015], Rabbit IgG, kappa

Specificité: The antibody is specific for human FcRn. The neonatal Fc receptor is a cell surface receptor that transfers passive humoral immunity from the mother to the newborn.

Attributs du produit:

Original Species of Ab: Mouse

Original Format of Ab: IgG1

Purification: Protein A affinity purified

Immunogène: The original antibody was generated by immunizing Balb/c mice with recombinant FcRn.

Isotype: IgG kappa

Information d'application

Indications d'application: The antibody was employed in blocking experiments with HEK293 cells that overexpress FcRn. The results showed that the antibody has a good effect of blocking the binding of IgG to FcRn at the cellular level (IC50: 11.4nM). The effect of the antibody was tested in human FcRn transgenic mice. The antibody was able to increase IgG catabolism in vivo by blocking FcRn binding (CN113484526).

Commentaires:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG1 format for improved compatibility with existing reagents assays and techniques.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Détails sur FcRn

Antigène: FcRn (neonatal Fc Receptor (FcRn))

Autre désignation: FcRn

Sujet: IgG receptor FcRn large subunit p51, FCGRT, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor

UniProt: P55899

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process