ORAI1 anticorps

N° du produit ABIN7565939

L’anticorps Lapin Polyclonal anti-ORAI1 a été validé pour WB. Il convient pour détecter ORAI1 dans des échantillons de Humain.

Aperçu rapide pour ORAI1 anticorps (ABIN7565939)

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ORAI1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ORAI1 anticorps

Fonction: ORAI1 Antibody

Réactivité croisée (Details): Anti-ORAI-1 antibody is directed against the human ORAI-1.

Attributs du produit: Synonyms: rabbit anti-ORAI-1 Antibody, Calcium release-activated calcium channel protein 1, orai-1, Transmembrane protein 142A, ORAI1, CRACM1, TMEM142A

Purification: The product was prepared from monospecific antiserum by delipidation and defibrination.

Stérilité: Sterile filtered

Immunogène:

Immunogen: This whole rabbit serum was prepared by repeated immunizations with a recombinant fusion protein.

Immunogen Type: Recombinant Protein

Information d'application

Indications d'application: Application Note: Anti-ORAI-1 has been tested for use in western blotting. Specific conditions for reactivity should be optimized by the end user. Expect bands approximately 32.7 kDa by western blotting in the appropriate cell lysate or extract. Western Blot Dilution: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 45 mg/mL

Buffer:

Buffer: 0.01 M Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store vial at -20° C or below prior to opening. This vial contains a relatively low volume of reagent (25 μL). To minimize loss of volume dilute 1:10 by adding 225 μL of the buffer stated above directly to the vial. Recap, mix thoroughly and briefly centrifuge to collect the volume at the bottom of the vial. Use this intermediate dilution when calculating final dilutions as recommended below. Store the vial at -20°C or below after dilution. Avoid cycles of freezing and thawing.

Date de péremption: 12 months

Détails sur ORAI1

Antigène: ORAI1 (ORAI Calcium Release-Activated Calcium Modulator 1 (ORAI1))

Autre désignation: ORAI1

Sujet: Background: The ORAI-1 gene codes for the calcium release-activated calcium (CRAC) channel subunit in humans. The CRAC channel subunit mediates calcium influx when activated by the calcium sensor, STIM1, following depletion of intracellular calcium stores. CRAC channels are the primary pathway for calcium influx in T-cells and promote the immune response to pathogens through activation of the transcription factor NFAT. Defects in this gene can be a cause of immune dysfunction due to inactivation of T-cells.

ID gène: 84876

NCBI Accession: NP_116179

UniProt: Q96D31

Pathways: TCR Signaling, BCR Signaling