IDH1 anticorps (R132H)

N° du produit ABIN7566428

L’anticorps Souris Monoclonal anti-IDH1 a été validé pour IHC et ELISA. Il convient pour détecter IDH1 dans des échantillons de Humain.

Aperçu rapide pour IDH1 anticorps (R132H) (ABIN7566428)

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp IDH1 est non-conjugé

Application: Immunohistochemistry (IHC), ELISA

Clone: AG-IHC132

Détail du produit anti-IDH1 anticorps

Épitope: R132H

Fonction: anti-Isocitrate Dehydrogenase 1 [IDH1] (R132H Mutant) (human), mAb (AG-IHC132)

Attributs du produit:

Monoclonal Antibody. Recognizes human IDH1 mutated at R132H. Applications: ELISA, IHC. Isotype: Mouse IgG1. Clone: AG-IHC132. Liquid. In Tris Buffer, pH 7.4, containing 1 % BSA and <0.1 % sodium azide. Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).

Isocitrate Dehydrogenase 1 (IDH1) is a soluble, cytosolic enzyme involved in the TCA metabolic cycle. The most notable mutation in this enzyme, R132H, is clinically indicated in the majority of astrocytomas and oligodendroglial tumors, with the mutation being associated with more favourable prognosis and increased survival in those patients. IDH1 R132H is also useful in the differential diagnosis between anaplastic glioma and glioblastoma. This antibody is intended to qualitatively identify by light microscopy the presence of associated antigens in sections of formalin-fixed, paraffin-embedded tissue sections using IHC test methods. It has been optimized and validated using the BOND-MAX fully automated IHC&ISH stainer (see Protocol).

Purification: Protein A/G purified.

Immunogène: Synthetic IDH1 peptide.

Isotype: IgG1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In Tris Buffer, pH 7.3 - 7.7, containing 1 % BSA and <0.1 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire:

Stable for at least 1 year after receipt when stored at +4°C.

Détails sur IDH1

Antigène: IDH1 (Isocitrate Dehydrogenase 1 (NADP+), Soluble (IDH1))

Autre désignation: Isocitrate Dehydrogenase 1 [IDH1]

UniProt: O75874

Pathways: L'effet Warburg