Neurotrophin 3 anticorps (Pro-Domain)

N° du produit ABIN7886734

Cet anticorps anti-Neurotrophin 3 Polyclonal Lapin (ABIN7886734) détecte spécifiquement Neurotrophin 3 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Neurotrophin 3 anticorps (Pro-Domain) (ABIN7886734)

Antigène: Neurotrophin 3 (NTF3)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neurotrophin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Détail du produit anti-Neurotrophin 3 anticorps

Épitope: AA 89-103, Pro-Domain

Fonction: A Rabbit Polyclonal Antibody to proNT-3

Séquence: (C)DTELLRQQRR YNSPR

Réactivité croisée (Details): The antibody is specific for proNT-3, it does not crossreact with proNGF, proBDNF or mature NT-3.

Homologie: Rat,mouse - identical

Attributs du produit: Highly specific antibody directed against an epitope of human pro. Anti-pro Antibody (ABIN7581927) can be used in western blot and immunohistochemistry applications. It has been designed to recognize pro from rat, mouse and human samples. The antibody does not cross reacts with mature , pro- and mature NGF or pro- and mature BDNF.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DTELLRQQRRYNSPR, corresponding to amino acid residues 89-103 of human NT-3 (precursor)

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:300-1:600

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neurotrophin 3

Antigène: Neurotrophin 3 (NTF3)

Autre désignation: NTF3

Sujet:

Synonyms: pro-Neurotrophin 3, proNTF3

Description: Brain derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that includes nerve growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5).All neurotrophins are synthesized as preproneurotrophin precursors that are subsequently processed within the intracellular transport pathway to yield proneurotrophins. These are further processed to generate the mature form. The mature form of BDNF is a non-covalent stable homodimer that can be secreted in both constitutive and regulated pathways.Until recently, the functional role of the neurotrophin prodomain was thought to assist in the correct folding of the mature protein and the sorting of the neurotrophin into the constitutive or regulated secretory pathway. However, a growing body of evidence suggests that the uncleaved proneurotrophin precursors can be secreted from cells and that they may mediate different biological functions. Several studies implicate both proNGF and proBDNF in several physiological and pathological conditions.It remains to be established whether proNT-3 has different biological functions than the mature NT-3 neurotrophin.

ID gène: 4908

UniProt: P20783

Pathways: Signalisation RTK, Neurotrophin Signaling Pathway