NPM1 anticorps (AA 1-294)

N° du produit ABIN7596068

Cet anticorps anti-NPM1 est un anticorps Souris Monoclonal détectant NPM1 dans WB, IF, ELISA, FACS et ICC. Adapté pour Humain.

Aperçu rapide pour NPM1 anticorps (AA 1-294) (ABIN7596068)

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp NPM1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: AT23F1

Détail du produit anti-NPM1 anticorps

Épitope: AA 1-294

Fonction: Human NPM1 antibody

Purification: Purified

Immunogène: Recombinant human NPM1(1-294aa) purified from E. coli

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate-Buffered Saline ( pH 7.4) with 0.02 % Sodium Azide, 10 % glycerol

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C,-80 °C

Stockage commentaire: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Détails sur NPM1

Antigène: NPM1 (Nucleophosmin (Nucleolar phosphoprotein B23, Numatrin) (NPM1))

Autre désignation: NPM1

Sujet: NPM1 is associated with nucleolar ribonucleoprotein structures and bind single-stranded and double-strandednucleic acids, but it binds preferentially G-Quadruplex forming nucleic acids. It is involved in the biogenesisof ribosomes and may assist small basic proteins in their transport to the nucleolus. Its regulation throughSUMOylation (by SENP3 and SENP5) is another facet of the proteins's regulation and cellular functions.It is located in the nucleolus, but it can be translocated to the nucleoplasm in case of serum starvation ortreatment with anticancer drugs. The protein is phosphorylated. Chromosomal aberrations involving NPM1 werefound in patients with non-Hodgkin lymphoma, acute promyelocytic leukemia, myelodysplastic syndrome, and acutemyelogenous leukemia. It has been found in the cytoplasm in patients with primary acute myelogenous leukemia.

NCBI Accession: NP_002511

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly