CDR2 anticorps (AA 1-441)

N° du produit ABIN7599397

Cet anticorps Lapin Polyclonal détecte spécifiquement CDR2 dans ELISA, IHC, WB et FACS. Il présente une réactivité envers Humain.

Aperçu rapide pour CDR2 anticorps (AA 1-441) (ABIN7599397)

Antigène: CDR2 (Cerebellar Degeneration-Related Protein 2, 62kDa (CDR2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDR2 est non-conjugé

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Flow Cytometry (FACS)

Détail du produit anti-CDR2 anticorps

Épitope: AA 1-441

Fonction: Anti-CDR2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-CDR2 Antibody Picoband® (ABIN7599397). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human CDR2 recombinant protein (Position: M1-D441).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Fletcher, C. F., Okano, H. J., Gilbert, D. J., Yang, Y., Yang, C., Copeland, N. G., Jenkins, N. A., Darnell, R. B. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. Genomics 45: 313-319, 1997. 2. Furneaux, H. M., Rosenblum, M. K., Dalmau, J., Wong, E., Woodruff, P., Graus, F., Posner, J. B. Selective expression of Purkinje-cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. New Eng. J. Med. 322: 1844-1851, 1990. 3. Gress, T., Baldini, A., Rocchi, M., Furneaux, H., Posner, J. B., Siniscalco, M. In situ mapping of the gene coding for a leucine zipper DNA binding protein (CDR 2) to the region between two rare fragile sites of autosome 16 (16p12-p13.1). (Abstract) Cytogenet. Cell Genet. 58: 1999-2000, 1991.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg NaN₃.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur CDR2

Antigène: CDR2 (Cerebellar Degeneration-Related Protein 2, 62kDa (CDR2))

Autre désignation: CDR2

Sujet:

Synonyms: Cerebellar degeneration-related protein 2, Major Yo paraneoplastic antigen, Paraneoplastic cerebellar degeneration-associated antigen, CDR2, PCD17

Tissue Specificity: Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

Background: Cerebellar degeneration-related protein 2 is a protein that in humans is encoded by the CDR2 gene. By a combination of study of rodent/human somatic cell hybrids and in situ hybridization, this gene is assigned to 16p13.1-p12. The onconeuronal cerebellar degeneration-related antigen Cdr2 is associated with paraneoplastic syndromes. Neoplastic expression of Cdr2 in ovary and breast tumors triggers an autoimmune response that suppresses tumor growth by developing tumor immunity, but culminates in cerebellar degeneration when Cdr2-specific immune cells recognize neuronal Cdr2.

Poids moléculaire: 62 kDa

ID gène: 1039

UniProt: Q01850