RAGE anticorps (AA 24-320)

N° du produit ABIN7600824

Cet anticorps Lapin Polyclonal détecte spécifiquement RAGE dans WB et ELISA. Il présente une réactivité envers Souris et Rat.

Aperçu rapide pour RAGE anticorps (AA 24-320) (ABIN7600824)

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAGE est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-RAGE anticorps

Épitope: AA 24-320

Fonction: Anti-Ager Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-Ager Antibody Picoband® (ABIN7600824). Tested in ELISA, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived mouse Ager recombinant protein (Position: Q24-E320).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Mouse, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Bierhaus, A., Haslbeck, K.-M., Humpert, P. M., Liliensiek, B., Dehmer, T., Morcos, M., Sayed, A. A. R., Andrassy, M., Schiekofer, S., Schneider, J. G., Schulz, J. B., Heuss, D., and 12 others. Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J. Clin. Invest. 114: 1741-1751, 2004. 2. Chavakis, T., Bierhaus, A., Al-Fakhri, N., Schneider, D., Witte, S., Linn, T., Nagashima, M., Morser, J., Arnold, B., Preissner, K. T., Nawroth, P. P. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment. J. Exp. Med. 198: 1507-1515, 2003. 3. Deane, R., Yan, S. D., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., Zhu, H., Ghiso, J., and 11 others. RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nature Med. 9: 907-913, 2003.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur RAGE

Antigène: RAGE (AGER) (Advanced Glycosylation End Product-Specific Receptor (AGER))

Autre désignation: Ager

Sujet:

Synonyms: Tumor necrosis factor-inducible gene 6 protein,Hyaluronate-binding protein,TNF-stimulated gene 6 protein,TSG-6,Tumor necrosis factor alpha-induced protein 6,TNF alpha-induced protein 6,TNFAIP6,TSG6,

Tissue Specificity: Found in the synovial fluid of patients with rheumatoid arthritis. .

Background: Enables S100 protein binding activity, advanced glycation end-product binding activity, and heparin binding activity. Involved in several processes, including cellular response to amyloid-beta, negative regulation of long-term synaptic potentiation, and positive regulation of cytokine production. Acts upstream of or within several processes, including induction of positive chemotaxis, negative regulation of advanced glycation end-product receptor activity, and positive regulation of macromolecule metabolic process. Located in extracellular space and plasma membrane. Is expressed in several structures, including alimentary system, brain, genitourinary system, hemolymphoid system gland, and lung. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple), cardiovascular system disease (multiple), cystic fibrosis, kidney failure (multiple), and lupus nephritis. Orthologous to human AGER (advanced glycosylation end-product specific receptor).

Poids moléculaire: 43 kDa, 58 kDa

ID gène: 11596

UniProt: Q62151

Pathways: Carbohydrate Homeostasis, Toll-Like Receptors Cascades, Smooth Muscle Cell Migration, S100 Proteins