Metabotropic Glutamate Receptor 1 anticorps (AA 25-466)

N° du produit ABIN7600912

L’anticorps Lapin Polyclonal anti-Metabotropic Glutamate Receptor 1 a été validé pour WB, IHC, ELISA et FACS. Il convient pour détecter Metabotropic Glutamate Receptor 1 dans des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Metabotropic Glutamate Receptor 1 anticorps (AA 25-466) (ABIN7600912)

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Metabotropic Glutamate Receptor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Détail du produit anti-Metabotropic Glutamate Receptor 1 anticorps

Épitope: AA 25-466

Fonction: Anti-mGluR1/GRM1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-mGluR1/GRM1 Antibody Picoband® (ABIN7600912). Tested in ELISA, Flow Cytometry, IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human mGluR1/GRM1 recombinant protein (Position: R25-E466).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human, Mouse
ELISA, 0.1-0.5 μg/mL, -
1. Ganesh, S., Amano, K., Yamakawa, K. Assignment of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization. Cytogenet. Cell Genet. 88: 314-315, 2000. 2. Ortiz, P., Vanaclocha, F., Lopez-Bran, E., Esquivias, J. I., Lopez-Estebaranz, J. L., Martin-Gonzalez, M., Arrue, I., Garcia-Romero, D., Ochoa, C., Gonzalez-Perez, A., Ruiz, A., Real, L. M. Genetic analysis of the GRM1 gene in human melanoma susceptibility. Europ. J. Hum. Genet. 15: 1176-1182, 2007. 3. Sachs, A. J., Schwendinger, J. K., Yang, A. W., Haider, N. B., Nystuen, A. M. The mouse mutants recoil wobbler and nmf373 represent a series of Grm1 mutations. Mammalian Genome 18: 749-756, 2007.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.01 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur Metabotropic Glutamate Receptor 1

Antigène: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Autre désignation: GRM1

Sujet:

Synonyms: Calbindin, Calbindin D28, D-28K, Vitamin D-dependent calcium-binding protein, avian-type, CALB1, CAB27

Tissue Specificity: Detected in skin. In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells. Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.

Background: This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 132 kDa

ID gène: 2911

UniProt: Q13255