ACCN1 anticorps (AA 27-512)

N° du produit ABIN7601023

L’anticorps Lapin Polyclonal anti-ACCN1 a été validé pour WB, ELISA, FACS, IF et ICC. Il convient pour détecter ACCN1 dans des échantillons de Humain, Rat et Souris.

Aperçu rapide pour ACCN1 anticorps (AA 27-512) (ABIN7601023)

Antigène: ACCN1 (Amiloride-Sensitive Cation Channel 1, Neuronal (ACCN1))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACCN1 est non-conjugé

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-ACCN1 anticorps

Épitope: AA 27-512

Fonction: Anti-ACCN1/ASIC2 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-ACCN1/ASIC2 Antibody Picoband® (ABIN7601023). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human ACCN1/ASIC2 recombinant protein (Position: H27-C512).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Garcia-Anoveros, J., Derfler, B., Neville-Golden, J., Hyman, B. T., Corey, D. P. BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc. Nat. Acad. Sci. 94: 1459-1464, 1997. 2. Jahr, H., van Driel, M., van Osch, G. J. V. M., Weinans, H., van Leeuwen, J. P. T. M. Identification of acid-sensing ion channels in bone. Biochem. Biophys. Res. Commun. 337: 349-354, 2005. 3. Lu, Y., Ma, X., Sabharwal, R., Snitsarev, V., Morgan, D., Rahmouni, K., Drummond, H. A., Whiteis, C. A., Costa, V., Price, M., Benson, C., Welsh, M. J., Chapleau, M. W., Abboud, F. M. The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64: 885-897, 2009.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Détails sur ACCN1

Antigène: ACCN1 (Amiloride-Sensitive Cation Channel 1, Neuronal (ACCN1))

Autre désignation: ASIC2

Sujet:

Synonyms: Acid-sensing ion channel 2, ASIC2, Amiloride-sensitive brain sodium channel, Amiloride-sensitive cation channel 1, neuronal, Amiloride-sensitive cation channel neuronal 1, Brain sodium channel 1, BNC1, BNaC1, Mammalian degenerin homolog, MDEG, ASIC2, ACCN, ACCN1, BNAC1, MDEG

Tissue Specificity: Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.

Background: Amiloride-sensitive cation channel 1, neuronal, also known as ASIC2,?is a?protein?that in?humans?is encoded by the?ACCN1 gene. This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and acid-sensing (proton-gated) ion channel 3 has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified.?

Poids moléculaire: 58 kDa

ID gène: 40

UniProt: Q16515

Pathways: Sensory Perception of Sound