HTR2C anticorps (AA 372-458)

N° du produit ABIN7601526

Cet anticorps Lapin Polyclonal détecte spécifiquement HTR2C dans WB et ELISA. Il présente une réactivité envers Humain et Rat.

Aperçu rapide pour HTR2C anticorps (AA 372-458) (ABIN7601526)

Antigène: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HTR2C est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-HTR2C anticorps

Épitope: AA 372-458

Fonction: Anti-5-HT2C Receptor/HTR2C Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-5-HT2C Receptor/HTR2C Antibody Picoband® (ABIN7601526). Tested in ELISA, WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human 5-HT2C Receptor/HTR2C recombinant protein (Position: N372-V458).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Rat
ELISA, 0.1-0.5 μg/mL, -
1. Brennan, T. J., Seeley, W. W., Kilgard, M., Schreiner, C. E., Tecott, L. H. Sound-induced seizures in serotonin 5-HT-2C receptor mutant mice. Nature Genet. 16: 387-390, 1997. 2. Di Narzo, A. F., Kozlenkov, A., Roussos, P., Hao, K., Hurd, Y., Lewis, D. A., Sibille, E., Siever, L. J., Koonin, E., Dracheva, S. A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide. Hum. Molec. Genet. 23: 4801-4813, 2014. 3. Doe, C. M., Relkovic, D., Garfield, A. S., Dalley, J. W., Theobald, D. E. H., Humby, T., Wilkinson, L. S., Isles, A. R. Loss of imprinted snoRNA mbii-52 leads to increased 5htr2c pre-RNA editing and altered 5HT(2C)R-mediated behaviour. Hum. Molec. Genet. 18: 2140-2148, 2009.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur HTR2C

Antigène: HTR2C (5-Hydroxytryptamine (serotonin) Receptor 2C (HTR2C))

Autre désignation: HTR2C

Sujet:

Synonyms: Neutrophil cytosol factor 1, NCF-1, 47 kDa autosomal chronic granulomatous disease protein, 47 kDa neutrophil oxidase factor, NCF-47K, Neutrophil NADPH oxidase factor 1, Nox organizer 2, Nox-organizing protein 2, SH3 and PX domain-containing protein 1A, p47-phox, NCF1, NOXO2, SH3PXD1A

Tissue Specificity: Detected in peripheral blood monocytes and neutrophils (at protein level).

Background: This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders. Alternative splicing results in multiple different transcript variants.

Poids moléculaire: 75 kDa

ID gène: 3358

UniProt: P28335

Pathways: Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process, Feeding Behaviour