Melanophilin anticorps (AA 61-523)

N° du produit ABIN7602169

L’anticorps Lapin Polyclonal anti-Melanophilin a été validé pour WB, ELISA, IF et ICC. Il convient pour détecter Melanophilin dans des échantillons de Humain.

Aperçu rapide pour Melanophilin anticorps (AA 61-523) (ABIN7602169)

Antigène: Melanophilin (MLPH)

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Melanophilin est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Détail du produit anti-Melanophilin anticorps

Épitope: AA 61-523

Fonction: Anti-MLPH Antibody Picoband®

Attributs du produit: Anti-MLPH Antibody Picoband® (ABIN7602169). Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human Melanophilin/MLPH recombinant protein (Position: E61-L523). Human Melanophilin/MLPH shares 61.6% amino acid (aa) sequence identity with mouse Melanophilin/MLPH.

Information d'application

Indications d'application: Western blot, 0.1-0.25 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -
1. Cagdas, D., Ozgur, T. T., Asal, G. T., Tezcan, I., Metin, A., Lambert, N., de Saint Basile, G., Sanal, O. Griscelli syndrome types 1 and 3: analysis of four new cases and long-term evaluation of previously diagnosed patients. Europ. J. Pediat. 171: 1527-1531, 2012. 2. Dagnewu, K. Y., Ayele, A., Liu, L., Pramanik, R., Onoufriadis, A., Abebe, E., McGrath, J. A. Griscelli syndrome type 3 in Ethiopian sisters resulting from a homozygous missense mutation in MLPH. (Letter) Int. J. Derm. 59: e55-e57, 2020. 3. Demars, J., Iannuccelli, N., Utzeri, V. J., Auvinet, G., Riquet, J., Fontanesi, L., Allain, D. New insights into the melanophilin (MLPH) gene affecting coat color dilution in rabbits. Genes (Basel) 9: 430, 2018. Note: Electronic Article.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur Melanophilin

Antigène: Melanophilin (MLPH)

Autre désignation: MLPH

Sujet: Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. This gene encodes a member of the exophilin subfamily of Rab effector proteins. The protein forms a ternary complex with the small Ras-related GTPase Rab27A in its GTP-bound form and the motor protein myosin Va. A similar protein complex in mouse functions to tether pigment-producing organelles called melanosomes to the actin cytoskeleton in melanocytes, and is required for visible pigmentation in the hair and skin. A mutation in this gene results in Griscelli syndrome type 3, which is characterized by a silver-gray hair color and abnormal pigment distribution in the hair shaft. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Poids moléculaire: 85 kDa

ID gène: 79083