NLRP2 anticorps (AA 80-1044)

N° du produit ABIN7602506

Cet anticorps anti-NLRP2 est un anticorps Lapin Polyclonal détectant NLRP2 dans WB, ELISA, IF, IP, ICC et FACS. Adapté pour Humain.

Aperçu rapide pour NLRP2 anticorps (AA 80-1044) (ABIN7602506)

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NLRP2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-NLRP2 anticorps

Épitope: AA 80-1044

Fonction: Anti-NLRP2 Antibody Picoband®

Attributs du produit: Anti-NLRP2 Antibody Picoband® (ABIN7602506). Tested in WB, ICC/IF, IP, Flow Cytometry, ELISA applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human NLRP2 recombinant protein (Position: H80-D1044).

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunoprecipitation, 0.5-2 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., Tschopp, J. NALP3 forms an IL-1-beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 20: 319-325, 2004. 2. Bruey, J. M., Bruey-Sedano, N., Newman, R., Chandler, S., Stehlik, C., Reed, J. C. PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappa-B and caspase-1 activation in macrophages. J. Biol. Chem. 279: 51897-51907, 2004. 3. Kuchmiy, A. A., D'Hont, J., Hochepied, T., Lamkanfi, M. NLRP2 controls age-associated maternal fertility. J. Exp. Med. 213: 2851-2860, 2016.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur NLRP2

Antigène: NLRP2 (NLR Family, Pyrin Domain Containing 2 (NLRP2))

Autre désignation: NLRP2

Sujet: NACHT, LRR and PYD domains-containing protein 2 is a protein that in humans is encoded by the NLRP2 gene. This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms.

Poids moléculaire: 121 kDa

ID gène: 55655

Pathways: Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Inflammasome