Bax Inhibitor 1 anticorps (N-Term)

N° du produit ABIN7603199

Cet anticorps anti-Bax Inhibitor 1 est un anticorps Lapin Polyclonal détectant Bax Inhibitor 1 dans WB, IHC, ICC et IF. Adapté pour Humain.

Aperçu rapide pour Bax Inhibitor 1 anticorps (N-Term) (ABIN7603199)

Antigène: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Bax Inhibitor 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Détail du produit anti-Bax Inhibitor 1 anticorps

Épitope: N-Term

Fonction: Anti-BI-1/TMBIM6 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-BI-1/TMBIM6 Antibody Picoband® (ABIN7603199). Tested in IF, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: A synthetic peptide corresponding to a sequence at the N-terminus of human BI-1/TMBIM6, identical to the related mouse and rat sequences.

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Immunofluorescence, 5 μg/mL, Human
1. Bailly-Maitre, B., Fondevila, C., Kaldas, F., Droin, N., Luciano, F., Ricci, J.-E., Croxton, R., Krajewska, M., Zapata, J. M., Kupiec-Weglinski, J. W., Farmer, D., Reed, J. C. Cytoprotective gene bi-1 is required for intrinsic protection from endoplasmic reticulum stress and ischemia-reperfusion injury. Proc. Nat. Acad. Sci. 103: 2809-2814, 2006. 2. Carrara, G., Saraiva, N., Gubser, C., Johnson, B. F., Smith, G. L. Six-transmembrane topology for Golgi anti-apoptotic protein (GAAP) and Bax inhibitor 1 (BI-1) provides model for the transmembrane Bax inhibitor-containing motif (TMBIM) family. J. Biol. Chem. 287: 15896-15905, 2012. 3. Gross, M. B. Personal Communication. Baltimore, Md. 3/22/2016.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur Bax Inhibitor 1

Antigène: Bax Inhibitor 1 (TMBIM6) (Transmembrane BAX Inhibitor Motif Containing 6 (TMBIM6))

Autre désignation: TMBIM6

Sujet:

Synonyms: Prion-like protein doppel, PrPLP, Prion protein 2, PRND, DPL, UNQ1830/PRO3443

Tissue Specificity: Expressed in testis, in Sertoli cells, ejaculated spermatozoa and in seminal fluid (at protein level).

Background: Bax inhibitor 1 is a protein that in humans is encoded by the TMBIM6 gene. Enables endoribonuclease inhibitor activity and ubiquitin protein ligase binding activity. Involved in several processes, including negative regulation of RNA metabolic process, negative regulation of intrinsic apoptotic signaling pathway, and response to L-glutamate. Acts upstream of or within negative regulation of calcium ion transport into cytosol. Located in endoplasmic reticulum membrane and mitochondrial membrane. Biomarker of cervical squamous cell carcinoma and prostate carcinoma.

Poids moléculaire: 35 kDa

ID gène: 7009

UniProt: P55061

Pathways: Response to Water Deprivation, ER-Nucleus Signaling